Laura Obici Selected Research

Hereditary Autoinflammatory Diseases

1/2018	Updated overview of molecular pathways involved in the most common monogenic autoinflammatory diseases.
1/2018	Renal involvement in autoinflammatory diseases and inflammasome-mediated chronic kidney damage.
9/2004	First report of systemic reactive (AA) amyloidosis in a patient with the hyperimmunoglobulinemia D with periodic fever syndrome.

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Laura Obici Research Topics

Disease

55	Amyloidosis 09/2022 - 06/2002
19	Transthyretin-Related Hereditary Amyloidosis 01/2022 - 06/2012
17	Immunoglobulin Light-chain Amyloidosis 12/2019 - 05/2003
12	Polyneuropathies (Polyneuropathy) 01/2022 - 07/2013
11	Cardiomyopathies (Cardiomyopathy) 01/2021 - 05/2003
10	Amyloid Plaque 01/2021 - 06/2002
9	Familial Amyloid Neuropathies (Familial Amyloid Polyneuropathy) 01/2022 - 07/2013
8	Disease Progression 09/2022 - 11/2005
8	Fever (Fevers) 01/2020 - 09/2004
7	autosomal dominant familial Periodic fever 01/2021 - 03/2006
7	Necrosis 05/2017 - 08/2011
4	Familial Mediterranean Fever (Periodic Disease) 01/2021 - 05/2013
4	Mevalonate Kinase Deficiency 01/2019 - 09/2004
4	Familial Amyloidosis (Hereditary Amyloidosis) 01/2015 - 05/2004
3	Inflammation (Inflammations) 01/2022 - 01/2017
3	Renal Insufficiency (Renal Failure) 01/2022 - 09/2004
3	Glomerulonephritis 01/2022 - 07/2018
3	Diabetic Neuropathies (Diabetic Neuropathy) 01/2022 - 01/2019
3	Proteinuria 01/2021 - 03/2009
3	Cryopyrin-Associated Periodic Syndromes 01/2020 - 05/2013
3	Heart Failure 01/2019 - 05/2003
3	Hereditary Autoinflammatory Diseases 01/2018 - 09/2004
3	Chronic Kidney Failure (Chronic Renal Failure) 11/2012 - 06/2007
2	Amyloid Neuropathies (Amyloid Neuropathy) 06/2021 - 06/2020
2	Abdominal Pain (Pain, Abdominal) 01/2021 - 01/2020
2	Pain (Aches) 04/2020 - 09/2013
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2020 - 01/2019
2	Thrombocytopenia (Thrombopenia) 08/2019 - 07/2018
2	Interstitial Nephritis (Tubulointerstitial Nephritis) 06/2015 - 12/2005
2	Hypogonadism (Hypergonadotropic Hypogonadism) 06/2015 - 07/2007
2	Heart Diseases (Heart Disease) 04/2014 - 12/2011
2	Alzheimer Disease (Alzheimer's Disease) 09/2013 - 10/2005
2	Hypoalphalipoproteinemias (Hypoalphalipoproteinemia) 06/2011 - 12/2006
2	Rare Diseases (Rare Disease) 06/2011 - 12/2005
1	Pyelonephritis 01/2022
1	Hypotension (Low Blood Pressure) 01/2022
1	Paraganglioma (Paragangliomas) 01/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2021
1	Lymphadenopathy 01/2020
1	Sepsis (Septicemia) 01/2020

Drug/Important Bio-Agent (IBA)

37	Prealbumin (Transthyretin)IBA 09/2022 - 05/2004
34	Amyloid (Amyloid Fibrils)IBA 09/2022 - 06/2002
15	Proteins (Proteins, Gene)FDA Link 01/2021 - 11/2005
14	Apolipoprotein A-I (Apolipoprotein A1)IBA 01/2021 - 01/2003
8	Biomarkers (Surrogate Marker)IBA 04/2022 - 12/2011
7	Pharmaceutical PreparationsIBA 09/2022 - 06/2007
7	AA amyloidosisIBA 01/2022 - 09/2004
7	Colchicine FDA LinkGeneric 01/2021 - 01/2018
7	Dexamethasone (Maxidex)FDA LinkGeneric 04/2014 - 04/2004
6	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2022 - 05/2003
6	InotersenIBA 01/2022 - 07/2018
6	Melphalan (Alkeran)FDA LinkGeneric 04/2014 - 04/2004
5	pro-brain natriuretic peptide (1-76)IBA 05/2012 - 05/2003
4	Amyloidogenic ProteinsIBA 01/2016 - 06/2002
3	patisiranIBA 09/2020 - 01/2019
3	Blood Proteins (Serum Proteins)IBA 01/2018 - 05/2004
3	canakinumab FDA Link 01/2018 - 01/2017
3	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 01/2012 - 03/2009
3	Thalidomide (Thalomid)FDA Link 01/2012 - 04/2005
2	TroponinIBA 01/2022 - 12/2011
2	Antisense OligonucleotidesIBA 06/2021 - 08/2019
2	Serum Amyloid A Protein (Serum Amyloid A)IBA 01/2021 - 01/2013
2	HDL CholesterolIBA 01/2021 - 06/2015
2	GelsolinIBA 01/2020 - 05/2004
2	NLR ProteinsIBA 01/2020 - 01/2018
2	tafamidisIBA 03/2019 - 12/2013
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2019 - 04/2015
2	InflammasomesIBA 01/2018 - 01/2018
2	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 07/2007
2	Alkaline PhosphataseIBA 06/2015 - 05/2004
2	ApolipoproteinsIBA 05/2015 - 12/2006
2	Apolipoprotein A-II (Apolipoprotein A2)IBA 05/2015 - 05/2004
2	Diflunisal (Dolobid)FDA Link 12/2013 - 06/2012
2	Doxycycline (Periostat)FDA LinkGeneric 09/2013 - 06/2012
2	Bortezomib (Velcade)FDA Link 01/2012 - 02/2011
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2011 - 03/2006
2	CholesterolIBA 06/2011 - 12/2006
2	Immunoglobulin M (IgM)IBA 02/2011 - 03/2009
2	Troponin IIBA 11/2010 - 03/2009
1	LigandsIBA 06/2021
1	Retinal Pigments (Pigments, Visual)IBA 01/2021
1	Islet Amyloid PolypeptideIBA 01/2021
1	Epidermal Growth Factor (EGF)IBA 01/2021
1	fibulinIBA 01/2021
1	SynucleinsIBA 01/2021
1	Carrier Proteins (Binding Protein)IBA 01/2021
1	Atrial Natriuretic Factor (ANF)IBA 01/2021
1	C-Reactive ProteinIBA 01/2021
1	Extracellular Matrix ProteinsIBA 01/2021
1	SteroidsIBA 01/2020
1	Proton Pump InhibitorsIBA 01/2020
1	Cysteine (L-Cysteine)FDA Link 01/2020
1	CytokinesIBA 01/2020

Therapy/Procedure

9	Therapeutics 09/2022 - 04/2005
3	Liver Transplantation 09/2022 - 02/2013
3	Stem Cell Transplantation 04/2014 - 04/2004
2	RNAi Therapeutics 09/2020 - 01/2019
2	Renal Dialysis (Hemodialysis) 09/2013 - 11/2005
2	Drug Therapy (Chemotherapy) 02/2013 - 11/2010
1	Activities of Daily Living (ADL) 04/2020